Nuggets of Knowledge: Cholinesterase inhibitors – statistically significant versus clinically important differences?

Grapefruits and drugs: when is statistically significant clinically significant?

Editorial Lown et al. (1) report a significant advance in describing a new mechanism by which ingested nutrients may change exposure to drug therapy. Grapefruit juice was reported to increase plasma concentrations of felodipine and nifedipine when the drug was concurrently administered with grapefruit juice (2). The potential clinical importance of such an interaction was noted when cyclosporin...

A Framework for Finding Statistically Significant Differences

In the questionnaire analysis, finding whether there is a statistically significant difference between two or more groups in a continuous measure is one of the major problems in researches. However, it is difficult for researchers to solve the issue of finding possible statistically significant difference, namely “Statistically Significant Difference Unawareness Issue”. There are two causes to ...

Low bone mineral density with tenofovir: does statistically significant mean clinically significant?

Adults with human immunodeficiency (HIV) infection appear to have a greater prevalence of low bone mineral density (BMD) and of fractures than do adults without HIV infection [1,2]. HIV infection itself may contribute to this greater prevalence. HIV induces inflammation (a known association with accelerated BMD loss), and low BMD has been reported in individuals with untreated HIV infection [1,...

DBit: Assessing Statistically Significant Differences in CDN Performance

As the volume of content served by content distribution networks (CDNs) grows, these networks evolve to improve performance. Their performance is difficult to characterize because it depends on a number of factors. In this paper, we develop a methodology called DBit that can determine whether one CDN’s user-perceived performance is statistically different from another. We validate DBit and demo...

Conducting Tests for Statistically Significant Differences Using Forest Inventory Data